DESIGN AND EVALUATE MOUTH DISSOLVING TABLETS OF DIVALPROEX SODIUM USING SUPERDISINTEGRANT
Abstract
The aim of the present work was to formulate and evaluate mouth dissolving tablets of Divalproex sodium using superdisintegrants, exhibiting adequate mechanical strength and disintegration time. Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. In the present investigation, an attempt was made to improve the solubility and dissolution rate of a poorly soluble drug, Divalproex sodium by inclusion complex method using β -cyclodextrin. Hence formulate Divalproex sodium mouth dissolving tablets by using β-cyclodextrin and superdisintegrants to enhance the solubility of the drug.
Keyword : β -cyclodextrin, microcrystalline cellulose, croscarmellose sodium, Divalproex sodium.
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References
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